无抽搐电休克治疗阿尔茨海默病2例

Modified electroconvulsive therapy for Alzheimer's disease： a two-case report

中文关键词:  无抽搐电休克治疗  阿尔茨海默病  激越行为  精神分裂症

英文关键词:Modified electroconvulsive therapy  Alzheimer's disease  Agitation  Schizophrenia

中文摘要:

      阿尔茨海默病（AD）是一种常见的神经退行性疾病，除认知功能进行性衰退外，患者常伴随激越、攻击行为等，传统药物治疗（如抗精神病药）的效果有限且存在严重副反应。无抽搐电休克治疗（MECT）是一种改良的电休克疗法，广泛应用于精神疾病的治疗。本文报道了MECT对1例AD患者及1例精神分裂症共病AD患者激越、攻击行为障碍的治疗，并结合国内外相关研究，分析MECT在改善AD患者行为障碍方面的潜在作用，旨在为制定AD的MECT治疗方案提供临床参考。

英文摘要:

      Alzheimer's disease （AD） is a prevalent neurodegenerative disorder characterized by progressive cognitive decline and commonly accompanied by agitation and aggressive behaviors. Conventional pharmaceutical treatments， such as antipsychotics， often provide limited therapeutic benefits and pose considerable risks of adverse effects. Modified electroconvulsive therapy （MECT）， a refined adaptation of electroconvulsive therapy， has been widely utilized in the treatment of mental disorders. This article reported the treatment of agitation and aggressive behavior disorders in one AD patient and one patient with schizophrenia comorbid AD. Combined with relevant domestic and foreign research， it analyzed the potential role of MECT in improving behavioral disorders in AD patients， aiming to provide clinical references for formulating MECT treatment plans for AD.