客观睡眠时间短与慢性失眠障碍患者血脂异常的相关性

Correlation between objective short sleep duration and dyslipidemia in patients with chronic insomnia disorder

中文关键词:  慢性失眠障碍  客观睡眠时间  血脂异常  血脂谱

英文关键词:Chronic insomnia disorder  Objective sleep duration  Dyslipidemia  Lipid profile

中文摘要:

      背景 慢性失眠障碍已成为一项重要的公共卫生问题，其可能与血脂异常相关。既往针对慢性失眠障碍患者血脂异常的研究多集中于探讨主观睡眠时间不足与血脂异常的关系，关于客观睡眠时间不足与血脂异常关系的研究有限。目的 探讨慢性失眠障碍患者客观睡眠时间短与血脂异常之间的关系，以期为慢性失眠障碍患者血脂异常的预防和干预提供参考。方法 回顾性收集2022年8月—2023年11月在绵阳市第三人民医院住院治疗的、符合《国际睡眠障碍分类第三版》（ICSD-3）慢性失眠障碍诊断标准的患者103例。通过多导睡眠监测采集患者的客观睡眠时间。根据客观睡眠时间，将患者分为客观睡眠时间≥7 h组（n=71）和客观睡眠时间<7 h组（n=32）。采用二元Logistic回归分析探讨客观睡眠时间<7 h对血脂异常的影响。结果 在103例慢性失眠障碍患者中，检出存在血脂异常者59例（57.28%）。客观睡眠时间≥7 h组和客观睡眠时间<7 h组的血脂异常情况比较，差异有统计学意义（χ²=5.956，P<0.05）。与客观睡眠时间≥7 h组相比，客观睡眠时间<7 h组的高密度脂蛋白胆固醇（HDL-C）水平更低、睡眠效率更低，差异均有统计学意义（t=-2.003、-5.482，P<0.05或0.01）。二元Logistic回归分析结果显示，客观睡眠时间<7 h的慢性失眠障碍患者出现血脂异常的风险是客观睡眠时间≥7 h者的3.128倍（OR=3.128，95% CI：1.139~8.588）。结论 客观睡眠时间短可能是慢性失眠障碍患者出现血脂异常的危险因素。

英文摘要:

      Background Chronic insomnia disorder has become a significant public health issue， and it may be associated with dyslipidemia. Previous studies on dyslipidemia in patients with chronic insomnia disorder have mainly focused on exploring the relationship between subjective short sleep duration and dyslipidemia， while there have been limited studies on the relationship between objective short sleep duration and dyslipidemia.Objective To explore the relationship between objective short sleep duration and dyslipidemia in patients with chronic insomnia disorder， in order to provide references for the prevention and intervention of dyslipidemia in this population.Methods A total of 103 patients who were hospitalized at The Third Hospital of Mianyang from August 2022 to November 2023 and met the diagnostic criteria for chronic insomnia disorder as defined in the International Classification of Sleep Disorder， third edition （ICSD-3） were retrospectively collected. The objective sleep duration of the patients was obtained through polysomnography. The patients were divided into two groups based on their objective sleep duration： the group with objective sleep duration ≥ 7 hours （n=71） and the group with objective sleep duration < 7 hours （n=32）. Binary Logistic regression analysis was used to explore the impact of objective sleep duration < 7 hours on dyslipidemia.Results Among 103 patients with chronic insomnia disorder， 59 cases （57.28%） were identified with dyslipidemia. The comparison of dyslipidemia conditions between the group with objective sleep duration ≥ 7 hours and the group with objective sleep duration < 7 hours showed a statistically significant difference （χ²=5.956， P<0.05）. Compared with the group with objective sleep duration ≥7 hours， the group with objective sleep duration < 7 hours exhibited significantly lower high-density lipoprotein cholesterol levels， and reduced sleep efficiency （t=-2.003， -5.482， P<0.05 or 0.01）. Binary Logistic regression analysis results showed that the risk of abnormal blood lipids in patients with chronic insomnia disorder with objective sleep duration < 7 hours was 3.128 times higher than that of patients with objective sleep duration ≥ 7 hours （OR=3.128， 95% CI： 1.139–8.588）.Conclusion Objective short sleep duration may be a risk factor for dyslipidemia in patients with chronic insomnia disorder.