胃饥饿素对抑郁症患者认知功能的改善作用及机制

Improvement effect and mechanism of ghrelin on cognitive function in patients with depressive disorder

中文关键词:  胃饥饿素  抑郁症  认知功能

英文关键词:Ghrelin  Depressive disorder  Cognitive function

中文摘要:

      抑郁症是一种常见的精神障碍，抑郁症患者常出现认知功能受损，日常生活和社会功能受到显著影响。胃饥饿素与抑郁症之间相互作用的机制已被广泛研究，但目前尚缺乏对其进行总结和系统性梳理。本文对胃饥饿素改善抑郁症患者认知功能的效果和机制进行系统评价，为改善抑郁症患者的认知功能提供参考。于2024年10月20日，计算机检索中国知网、PubMed和Web of Science数据库，收集与胃饥饿素对抑郁症患者认知功能改善的效果及机制研究相关的文献。检索时限为建库至2024年10月20日。由两名研究者独立进行文献筛选，并提取纳入文献基本信息。共纳入9篇文献。结果显示，胃饥饿素可以通过减少炎症反应、调节氧化应激反应、激活环磷腺苷效应元件结合蛋白-脑源性神经营养因子（CREB-BDNF）信号通路等多种方式改善抑郁症患者的认知功能。

英文摘要:

      Depressive disorder is a common psychiatric condition clinically characterized by impaired cognitive function， which profoundly affects patients' daily living and social functioning. Despite extensive research on the mechanism underlying the interaction between ghrelin and depressive disorder， comprehensive reviews， summary， and systematic organization of these findings remain lacking. To address this gap， this study aims to conduct a systematic evaluation of the effects and mechanisms of ghrelin on cognitive function in patients with depressive disorder， thereby providing references for targeted clinical interventions. On October 20， 2024， literature exploring the role and mechanisms of ghrelin in improving cognitive function in depressive disorder was sourced from the CNKI， PubMed and Web of Science databases， covering the period from the inception of the database till October 20， 2024. Two researchers independently conducted literature screening and data extraction. Ultimately， 9 articles were included in this review. The findings suggest that ghrelin improves cognitive function in patients with depressive disorder through multiple mechanisms， including mitigating inflammatory responses， modulating oxidative stress， and activating the cyclic adenosine monophosphate response element binding protein-brain-derived neurotrophic factor （CREB-BDNF） signaling pathway.