卒中后抑郁的病理生理机制与治疗策略研究进展

Recent advances in pathophysiological mechanisms and treatment of post-stroke depression

中文关键词:  卒中后抑郁  病理生理机制  治疗

英文关键词:Post-stroke depression  Pathophysiological mechanism  Treatment

中文摘要:

      卒中后抑郁是卒中常见且严重的并发症，严重影响卒中患者的康复进程及生活质量，增加患者死亡率。尽管对卒中后抑郁的认识不断深入，但其临床诊疗仍面临许多挑战。本文通过对卒中后抑郁的病理生理机制及治疗策略进行综述，提供临床早期识别与精准治疗卒中后抑郁的相关证据，以期为改善卒中患者的康复和治疗效果提供参考。共纳入14篇原始文献，系统分析了影响卒中后抑郁的遗传因素、神经生物学因素、免疫学因素、社会心理因素以及治疗策略，为深入了解卒中后抑郁并制定综合治疗策略提供参考。

英文摘要:

      Post-stroke depression （PSD） represents a common and debilitating complication following stroke， substantially impeding neurorehabilitation outcomes and exerting a profound negative impact on patients' quality of life， while concurrently contributing to increased mortality rates. Despite a growing understanding of PSD， contemporary clinical management continues to encounter multifaceted challenges. This systematic review synthesizes extant literature to delineate pathophysiological mechanisms underlying PSD and to identify evidence-based interventions. By establishing a theoretical foundation， it aims to optimize early diagnostic protocols and personalized therapeutic regimens， thereby enhancing rehabilitation and therapeutic outcomes in stroke patients. Through rigorous evaluation of 14 original studies， this analysis comprehensively examines genetic factors， neurobiological aberrations， immunological factors， and psychosocial stressors contributing to PSD onset and progression， offering critical insights for developing comprehensive treatment strategies.［Funded by Science and Technology Plan Project of Yunnan Provincial Department of Science and Technology （number， 202101AY070001-048）］