无法忍受不确定性与强迫症精神病理的关系及脑神经机制

Relationship between intolerance of uncertainty and obsessive-compulsive disorder pathology and neurobiological mechanisms

中文关键词:  强迫症  无法忍受不确定性  磁共振成像  精神病理  神经机制

英文关键词:Obsessive-compulsive disorder  Intolerance of uncertainty  Magnetic resonance imaging  Psychopathology  Neural mechanisms

中文摘要:

      强迫症是一类具有高致残性的精神障碍，影响患者的社会功能及生活质量，并造成沉重的经济负担。无法忍受不确定性（IU）是指个体对不确定性情境或事件进行感知、解释和反应的认知偏差。IU与强迫症患者的认知模式密切相关，本文基于磁共振成像（MRI）技术探讨IU与强迫症精神病理特征关系的脑神经机制研究进展，并提出未来的研究方向，为开发更有效的强迫症治疗策略提供参考。

英文摘要:

      Obsessive-compulsive disorder （OCD） is a highly disabling mental disorder that impairs patients' social function and quality of life， and impose a substantial economic burden. Intolerance of uncertainty （IU） refers to a cognitive bias in perceiving， interpreting and responding to uncertain situations or events. IU is closely associated with the cognitive patterns of OCD patients. Based on magnetic resonance imaging （MRI）， this paper discusses the research progress of the relationship between IU and psychopathological characteristics of OCD， and put forward the research direction， aims to provide evidence-based references for the development of optimized therapeutic interventions for OCD.