伴自杀行为抑郁发作和精神分裂症患者睡眠脑电功率谱密度比较研究

A comparative study of sleep and power spectral density in depressive episode and schizophrenic patients with suicidal behavior

中文关键词:  抑郁发作  精神分裂症  自杀行为  多导睡眠监测  功率谱密度

英文关键词:Depressive episode  Schizophrenia  Suicidal behavior  Polysomnography  power spectral density

中文摘要:

      目的 比较伴自杀行为抑郁发作和精神分裂症患者睡眠脑电功率谱密度差异。方法 随机选取近1个月内出现自杀行为抑郁发作和精神分裂症患者各20例及20例正常对照组，采用失眠严重程度指数量表、睡眠信念与态度量表、梦魇严重程度指数、Epworth嗜睡量表评估主观睡眠，采用多导睡眠监测评估主观睡眠，通过睡眠脑电滤波器分析和处理脑电功率谱密度，并对比患者的主观睡眠、客观睡眠、睡眠脑电功率谱密度差异。结果 伴自杀行为抑郁发作和伴自杀行为精神分裂症主观睡眠、客观性睡眠和睡眠脑电功率谱密度无显著性差异（P＞0.05）。伴自杀行为抑郁发作和伴自杀行为精神分裂症的N2期、R期α波总功率，N2期、N3期、R期α平均功率较正常对照组显著性低（P<0.01），而N1期β平均功率，W期、N1期、N2期、R期δ波总功率，N2期、N3期、R期δ平均功率较正常对照组显著性高（P＞0.05）；伴自杀行为抑郁发作的W期α平均功率、W期δ平均功率、W期θ平均功率较正常对照组显著性高（P<0.05），N1期α波总功率较正常对照组显著性低（P<0.01）。结论 伴自杀行为抑郁发作和精神分裂症睡眠期α波功率较正常对照组显著性低（P<0.01），δ波功率较正常对照组显著性高（P<0.05）。伴自杀行为抑郁发作和精神分裂症患者睡眠脑电功率谱密度无显著性差异。

英文摘要:

      Objective To compare the sleep and power spectral density of depressive episode and schizophrenic patients with suicidal behavior.Methods 20 depressive episode patients and 20 schizophrenia patients with suicidal behavior and normal control group were selected.Subjective sleep was assessed by insomnia severity index scale, belief and attitude about sleep, disturbing dreams and nightmare severity index and Epworth Sleepiness Scale, subjective sleep was assessed by polysomnography monitoring, and power spectral density was analyzed and processed by sleep EEG filter,and to compare the differences of subjective sleep, objective sleep and sleep EEG power spectral density between them.Results There was no significant difference in subjective sleep, objective sleep and sleep EEG power spectral density between schizophrenia and depressive episode with suicidal behavior(P>0.05).α wave of power spectral density in N2、N3 and R stages of depressive episode and schizophrenia with suicidal behavior was significantly lower than that of the normal control group (P<0.01),and δ Wave of the power spectrum density in W, N1, N2, N3 and R stages was significantly higher than that in normal control group (P<0.05).depressive episode with suicidal behavior α Average power in W,δ Average power in W and θ average power was significantly higher than the normal control group (P<0.05),αtotal wave power in N1 was significantly lower than that of the normal control group (P<0.01).Conclusions αwave of power spectral density in sleep stages of depressive episode and schizophrenia with suicidal behavior was significantly lower than that of the normal control group (P<0.01),δ wave power was significantly higher than that of the normal control group (P<0.05),and there was no significant difference in the spectral density of sleep EEG power between depressive episode and schizophrenia with suicidal behavior..